NMNH Raises NAD+ Substantially More than NMN? Exploring the Science, Benefits, and NMNH Supplements

At the forefront of biohacking, nicotinamide adenine dinucleotide (NAD+) has emerged as a pivotal molecule for promoting enhanced cellular health and a longer, healthier lifespan. NAD+ plays an essential role in energy metabolism, DNA repair, and cellular function; however, its levels naturally decline with age. To counter this, supplements like NMN (nicotinamide mononucleotide) have gained popularity for their ability to boost NAD+ levels.

However, a newer compound, reduced NMN (dihydro nicotinamide mononucleotide), has recently gained attention for substantially raising NAD+ levels more than NMN in animal studies. In this article, we dive deep into what an NMNH supplement is, compare NMN vs NMNH, review the latest NMNH clinical studies, and explore why NMNH could be the next breakthrough in anti-aging science.

What is NMNH?

NMNH, or reduced nicotinamide mononucleotide (reduced NMN), is a form of NMN with an added hydrogen atom. This subtle molecular difference changes how NMNH behaves in the body, potentially making it a more potent NAD+ precursor. Unlike traditional NMN, which undergoes several enzymatic steps to convert into NAD+, NMNH appears to bypass some rate-limiting steps, leading to faster and higher increases in NAD+ levels.[1]

NMNH Raises NAD+ Substantially More than NMN? The Science Behind It

Animal studies have demonstrated that NMNH nearly doubles NAD+ levels in the blood compared to NMN. According to research published in the FASEB Journal and highlighted by Modern Healthspan, NMNH (reduced NMN) not only elevates blood NAD+ more rapidly but also sustains these elevated levels for over 24 hours, longer than NMN, whose effects tend to taper after about 20 hours [1].

Moreover, NMNH significantly boosts NAD+ in tissues where NMN typically shows limited effects, such as muscle, heart, and brain. This is particularly important because these organs are affected considerably during aging and play a central role in many age-related diseases.

NMNH Clinical Studies: What Does the Research Say?

While NMNH shows promising results in animal models and cell cultures, human clinical studies are currently limited. UthPeak NMNH is the only NMNH brand that has conducted clinical research, and it remains the world's most prominent (encompassing 80 participants) and longest (lasting 90 days) clinical study on NMNH.

UthPeak® NMNH is formulated to support cellular energy, cognitive function, and overall vitality by leveraging the enhanced bioavailability and potency of NMNH.

The current clinical trial has shown that UthPeak® NMNH can effectively

• 3X NAD+ INCREMENT

• 5 Years YOUNGER

• 35% Boost in ENERGY

• 31% Improvement in EMOTIONAL WELLNESS

Learn more clinical details on NMNH.

NMN vs NMNH Supplement: Key Differences and Benefits

Understanding the differences between NMN and NMNH supplements can help you make informed decisions about your health regimen.

Feature	NMN (Nicotinamide Mononucleotide)	NMNH (Nicotinamide Mononucleotide Hydrogen)
Molecular Structure	Standard NMN molecule	Reduced form with an extra hydrogen atom
NAD+ Boost Efficiency	Moderate, well-documented	Substantially higher and faster in preclinical studies
Tissue NAD+ Elevation	Limited in the muscle, heart, and brain	Significant elevation in these tissues
Clinical Research	Extensive animal and some human studies	Mostly preclinical; UthPeak® NMNH is the first NMNH brand to conduct clinical studies. (Phase I studies are now completed; Phases II are currently underway)
Metabolic Effects	Stimulates glycolysis and energy metabolism	Temporarily suppresses glycolysis and the TCA cycle
Safety Profile	Established, generally recognized as safe	UthPeak® NMNH declared GRAS by Effepharm (self-affirmed)
Availability	Widely available	Emerging, less common

Benefits of NMNH Supplementation

Based on current research, potential benefits of NMNH include:

• Enhanced NAD+ Levels: Faster and higher increases in NAD+ compared to NMN.[1]

• Improved Tissue Targeting: Boosts NAD+ in muscles, heart, and brain, potentially supporting physical performance, cardiovascular health, and cognitive function.[1]

• Sustained NAD+ Elevation: Longer-lasting NAD+ levels may translate to more consistent cellular support.[1]

• Cellular Regulation: The temporary suppression of glycolysis and the TCA cycle may regulate cell growth, potentially offering therapeutic avenues beyond the treatment of aging.[2]

Potential Risks and Considerations

UthPeak® NMNH is generally considered safe based on evaluations by Self-GRAS expert panels, with no signs of acute toxicity observed from preclinical and clinical studies.

In contrast, NMN has a more established safety record, with multiple human trials reporting good tolerance even at higher doses.

Both NMNH (reduced NMN) and NMN are regarded as safe due to evidence from completed toxicology and clinical studies. As NAD+ supplements, they are typically safe for daily use. However, potential side effects may include nervousness, headaches, and fatigue. It is essential to consult with a healthcare provider to determine the appropriate dosage and usage guidelines.

NMN vs NMNH Supplement: Which One Should You Choose?

• Choose NMN if:

  • You prefer a supplement with extensive human clinical backing.

  • You want a well-established safety profile.

  • You are looking for moderate but reliable NAD+ enhancement.

• Consider NMNH if:

  • You are interested in cutting-edge supplements with potentially superior NAD+ boosting ability.

  • You want to target NAD+ elevation in muscle, heart, or brain tissues more effectively.

Regardless of the option you choose, always select a reliable manufacturer that uses clinically backed ingredients. If you wish to add any of these to your current supplements, consult a specialist first.

Conclusion: The Future of NAD+ Supplementation

The discovery that NMNH raises NAD+ substantially more than NMN opens exciting possibilities for anti-aging and metabolic health.

For those eager to explore NMNH supplementation, products like UthPeak® NMNH offer access to this promising molecule. However, consulting healthcare providers to match your health goals and monitoring emerging research is essential.

Are you interested in the potential of UthPeak® NMNH? Contact us for the latest trends and expert guidance on clinical trial planning. Stay ahead of your product portfolio with UthPeak® NMNH today!

Contact Us!

Reference:

[1] Zapata-Pérez, R., Tammaro, A., Schomakers, B. V., Scantlebery, A. M. L., Denis, S., Elfrink, H. L., Giroud-Gerbetant, J., Cantó, C., López-Leonardo, C., McIntyre, R. L., van Weeghel, M., Sánchez-Ferrer, Á., & Houtkooper, R. H. (2021). Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 35(4), e21456. https://doi.org/10.1096/fj.202001826R

[2] Liu, Y., Luo, C., Li, T., Zhang, W., Zong, Z., Liu, X., & Deng, H. (2021). Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth. Journal of Proteome Research, 20(5), 2596–2606. https://doi.org/10.1021/acs.jproteome.0c01037