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A Comparison Between NMN and Reduced Form NMN

NMN and NMNH (Reduced NMN) both belong to the house of NAD+ precursors, one of the scientifically recognized factors impacting the aging process. Due to their function in cellular health energy metabolism and DNA repair, they have been garnering significant attention in the supplement market, especially among health enthusiasts.

Let's delve into the revolutionary potentials of NMNH (Reduced NMN) and its differentiation from NMN.

Abbreviations

To clarify our discussion, let's define the key abbreviations used in this comparison of NMNH and NMN:

 

NMNH: Reduced Nicotinamide Mononucleotide

NMN: Nicotinamide Mononucleotide

NAD+: Nicotinamide Adenine Dinucleotide

NR: Nicotinamide Riboside

NMNH

NMNH (Reduced NMN) or dihydronicotinamide mononucleotide, stands for Reduced Nicotinamide Mononucleotide.

 

Studies in animal models suggest that NMNH (Reduced NMN) has the potential to rapidly and significantly increase NAD levels, surpassing NMN or NR, presenting an exciting avenue for NAD replenishment.

NMN

NMN is called Nicotinamide Mononucleotide and is a NAD+ booster with proven benefits.

 

NMN acts as a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme involved in energy production, DNA repair, and cellular regulation.

NMNH: Impacting NAD+ in Ways Like Never Before

Research indicates that NMNH is potentially more effective than NMN in boosting NAD+ levels. A study* published in the prestigious journal of the Federation of American Societies for Experimental Biology (FASEB) has shed light on NMNH's remarkable attributes:

10X NAD+ Surge

NMNH (Reduced NMN) takes the concept of NAD+ enhancement to new heights. In a head-to-head comparison, NMNH exhibited exceptional potency compared to Nicotinamide Mononucleotide (NMN). NMNH demonstrated a nearly 10-fold increase in cellular NAD+ levels, showcasing its remarkable efficacy.

UTHPEAK NMNH | 10X NAD+ Surge Chart

24 Hrs Steady NAD+ Increase

The dynamics of NMNH (Reduced NMN) are captivating. Upon supplementation, NMNH rapidly elevated NAD+ levels within just 15 minutes at an unprecedented pace. What sets NMNH apart is its ability to sustain this elevation, with NAD+ levels remaining 2-fold for up to 24 hours. This contrasts sharply with the quick plateau observed with NMN.

UTHPEAK NMNH | 20 Hrs Steady NAD+ Increase Chart

Multi-Tissue NAD+ Influence, 5 Organs

NMNH (Reduced NMN)'s impact reverberates across various tissues. Notably, NMNH triggered significant increases in NAD+ levels within vital organs such as the liver and kidney, signaling its potential for comprehensive cellular support. The brain, muscle, brown adipose tissue, and heart—all critical hubs of biological activity—also experienced heightened NAD+ levels, a feat not replicated by NMN.

Multi-Tissue NAD+ Influence, 5 Organs | UTHPEAK NMNH

NMNH V.S. NMN (NAD+ Rise)

Table showing a comparison of the properties of NMN and NMNH in these areas: maximum dosage, NAD+ rise, multi-tissue NAD+ rise and adverse effect.

Our clinical studies have revealed a striking finding: the NAD+ increase triggered by NMNH (Reduced NMN) is five times greater than that achieved by NMN. This substantial difference is a clear testament to NMNH's superior efficacy in boosting cellular NAD+ levels.


While our current research underscores the promising benefits of NMNH, it's important to note that we are still investigating its full safety profile.

NMNH V.S. NMN (Multi-Tissue NAD+ Rise)

Two female scientists conducting experiments in a laboratory to find the difference between NMNH and NMN.

NMNH stands out for its efficiency in boosting NAD+ levels, requiring only one-tenth the dosage compared to NMN to achieve comparable results. This efficiency signifies a significant advancement in NAD+ supplementation, as it suggests that smaller amounts of NMNH can deliver the same beneficial increase in NAD+ levels that NMN provides, but with reduced dosage requirements. This not only makes NMNH a more potent option but also potentially enhances its appeal and usability for consumers seeking effective NAD+ enhancement solutions.

Comparison Between NMNH and NMN

When comparing NMNH and NMN, several key differences emerge:

Molecular and Chemical Composition

The molecular structure and chemical composition of NMNH and NMN are fundamentally different. NMNH is a reduced form of NMN, a modification that significantly enhances its ability to raise NAD+ levels in the body. This structural difference is key to NMNH's enhanced efficacy, enabling more efficient cellular uptake and utilization, which in turn contributes to more effective NAD+ replenishment.

Health Implications

The impact of NMNH on health appears to be more extensive and potent compared to NMN. NMNH's capability to influence multiple tissues and sustain NAD+ boosting points to its potential for offering comprehensive health benefits. Particularly in the realms of anti-aging and cellular health, NMNH's multifaceted influence suggests that it could be more effective in combating age-related decline and supporting cellular functions across a wider array of body tissues.

NAD+ Level Rise

Empirical evidence indicates that NMNH induces a significantly higher and more prolonged increase in NAD+ levels when compared to NMN. This difference is crucial, as NAD+ is a vital coenzyme that plays a central role in metabolic processes, DNA repair, and energy production. The heightened and sustained elevation of NAD+ levels by NMNH could translate into more pronounced health benefits, including better cellular energy production and enhanced repair and maintenance of cellular components.

Dosage Considerations

Both NMNH and NMN are undergoing extensive testing to determine their optimal dosages. NMNH's enhanced potency potentially allows for lower dosage requirements compared to NMN, which can directly impact the end-consumer experience. A smaller dosage of NMNH means that supplements can be produced in smaller capsules or tablets, making them more convenient and appealing for daily consumption. This precise dosage determination is crucial for guiding the practical application of health supplements and treatments, ensuring users receive effective, manageable, and consumer-friendly options for their wellness routines.


NMNH (Reduced NMN) has demonstrated the potential to surpass conventional NAD+ precursors in terms of efficacy in cellular health enhancement. Learn how we ensure the ultimate safety and efficacy through the UthPeak™ preclinical and clinical trials and studies.

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  • Is NAD approved by FDA?
    Currently, NAD and its precursors, like NMNH and NMN, fall under the category of dietary supplements. The Food and Drug Administration (FDA) doesn’t grant approval to dietary supplements in the same manner it does for pharmaceutical drugs. Instead, it monitors the market for any supplements that might pose safety concerns or make unsubstantiated health claims. Manufacturers are responsible for ensuring their products are safe and that any health claims are supported by evidence. While NAD supplements are available on the market, consumers should look for products from reputable sources to ensure quality and safety.
  • Is NMNH the same as NMN?
    NMNH (Reduced Nicotinamide Mononucleotide) and NMN (Nicotinamide Mononucleotide) are related but distinct compounds involved in the body's NAD+ biosynthesis pathway. NMNH is the reduced form of NMN, meaning it has undergone a bio-reduction reaction that changes its molecular structure. NMNH is metabolized through a different, NRK and NAMPT-independent, pathway, which potentially enhances NMNH's ability to increase NAD+ levels to a much higher extent and faster than NMN. While both are precursors to NAD+ and share the goal of boosting NAD+ levels within the body, their differences in chemical structures influence their stability and effectiveness in supplement forms.
  • Are there any dangers taking NAD supplements?
    Like with any supplement, there can be risks associated with taking NAD supplements, especially if taken inappropriately or in excessive amounts. Potential dangers could include interactions with medications, underlying health conditions, or side effects such as nausea, fatigue, and headaches in some individuals. However, when used under the guidance of a healthcare professional and within recommended dosages, NAD supplements are generally considered safe for most people. It's crucial to consult with a healthcare provider before starting any new supplement regimen.
  • How does the duration of NAD+ increase compare between NMNH and NMN?
    The duration of the NAD+ increase achieved by NMNH is longer compared to NMN. While NMN provides a boost in NAD+ levels, this tends to plateau relatively quickly. In contrast, NMNH not only elevates NAD+ levels rapidly but also sustains this elevation for a longer period, extending the duration of its beneficial effects.
  • Can NMNH be obtained through diet?
    Currently, NMNH is not typically obtained through diet. It is developed and administered as a supplement, primarily due to its specific molecular structure that is not readily available in dietary sources. As a specialized compound, NMNH is usually manufactured through a controlled process to ensure its efficacy and purity for supplemental use.
  • Is NMNH more effective in specific organs compared to NMN?
    Yes, NMNH appears to be more effective in specific organs compared to NMN. NMNH has shown a more significant impact on NAD+ levels in vital organs such as the liver, kidney, and brain. This indicates that NMNH could offer more comprehensive support for cellular health across these critical organs.
  • What are the implications of the difference between NMNH and NMN?
    The differences between NMNH and NMN have significant implications. NMNH's superior ability to increase and sustain higher NAD+ levels suggests it could be more effective in promoting cellular health and combating aging processes. This could lead to NMNH being preferred in therapeutic applications targeting age-related decline and diseases where cellular energy and repair mechanisms are crucial.
  • How does NMNH perform compared to NMN in increasing NAD+ levels?
    NMNH has been shown to outperform NMN in increasing NAD+ levels. Studies indicate that NMNH can raise NAD+ levels more significantly and rapidly than NMN. The enhanced molecular structure of NMNH allows for more efficient cellular uptake, leading to a more pronounced increase in NAD+ levels.
  • Can NMNH impact multiple tissues and organs?
    Indeed, NMNH can impact multiple tissues and organs. Its ability to increase NAD+ levels is not limited to a single type of tissue or organ. NMNH has been observed to enhance NAD+ levels in a variety of tissues, including the heart, brain and muscle, indicating its potential for widespread cellular support.
  • What makes UthPeak™ NMNH unique in the market?
    UthPeak™ NMNH boasts an advanced, patent-pending crystalline form, offering higher purity and stability compared to standard NMN supplements. This distinctive characteristic ensures it delivers enhanced and sustained NAD+ boosting effects, positioning UthPeak™ as a frontrunner in the NAD+ supplement market.
  • How long does the NAD+ boost from UthPeak™ NMNH last?
    UthPeak™ NMNH is notable for its longevity. It raises NAD+ levels for up to 6 hours and maintains them at a high level for about 24 hours. This extended duration surpasses that of many other NAD+ precursors, offering prolonged benefits for users.
  • How does UthPeak™ NMNH differ from other NAD+ precursors?
    UthPeak™ NMNH sets itself apart from other NAD+ precursors primarily through its exceptional potency. As a reduced form of nicotinamide mononucleotide (NMN), it can increase NAD+ levels up to ten times more effectively than similar compounds. The proprietary crystalline structure of UthPeak™ NMNH enhances its stability, ensuring it maintains its integrity and effectiveness in boosting NAD+ levels.
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Frequently Asked Questions About Comparison Between NMNH and NMN

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